When running Windows clients in the “cloud”, i.e. virtual Windows clients, there are several things to note and to take into considerations. For instance what will happen every wednesday night at 01:00 when all your X number of Windows clients will start defragmenting their virtual disks? Probably this scenario will significantly impact performance negatively on your virtual cluster disks.
There are many more actions you can take to optimize your clients in a VDI scenario and thanks to Jonathan Bennett this action is very smooth. Run the tool VDI Optimizer and choose what you want to be turned off and out comes a VBscript that you can run for instance at deploy time.